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NR4A1

GENERAL INFORMATION

Gene name

 NR4A1

Gene description

 Nuclear receptor subfamily 4, group A, member 1

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MCF7, SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NR4A1 (HGNC Symbol)

Synonyms

 GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3

Description

 Nuclear receptor subfamily 4, group A, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52022832 - 52059507

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123358 (version 83.38)

Entrez gene

 3164

UniProt

 P22736 (UniProt - Evidence at protein level)

neXtProt

 NX_P22736

Antibodypedia

 NR4A1 antibodies

PROTEIN BROWSER
«
NR4A1-002
NR4A1-003
NR4A1-004
NR4A1-006
NR4A1-010
NR4A1-011
NR4A1-012
NR4A1-013
NR4A1-016
NR4A1-021
NR4A1-201
NR4A1-202
NR4A1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR4A1-002
ENSP00000378301
ENST00000394824
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
A0A024R126 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d
Show all
Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 598 aa
64.5 kDa 		No 0
NR4A1-003
ENSP00000440864
ENST00000545748
F5GXF0 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035259 [glucocorticoid receptor binding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071310 [cellular response to organic substance]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 652 aa
70.5 kDa 		No 0
NR4A1-004
ENSP00000449539
ENST00000550082
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 611 aa
66 kDa 		No 0
NR4A1-006
ENSP00000449587
ENST00000548232
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 325 aa
33.8 kDa 		No 0
NR4A1-010
ENSP00000456776
ENST00000553200
H3BSM8 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.5 kDa 		No 0
NR4A1-011
ENSP00000456633
ENST00000548977
H3BSB9 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
Show all
 119 aa
12.5 kDa 		No 0
NR4A1-012
ENSP00000457070
ENST00000546842
H3BT85 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0043565 [sequence-specific DNA binding]
Show all
 302 aa
31.3 kDa 		No 0
NR4A1-013
ENSP00000449858
ENST00000550763
F8VVX9 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
Show all
 148 aa
15.6 kDa 		No 0
NR4A1-016
ENSP00000455767
ENST00000550582
H3BQG5 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 120 aa
12.5 kDa 		No 0
NR4A1-021
ENSP00000455399
ENST00000562373
H3BPN8 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
Show all
 150 aa
15.5 kDa 		No 0
NR4A1-201
ENSP00000243050
ENST00000243050
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
A0A024R126 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d
Show all
Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 598 aa
64.5 kDa 		No 0
NR4A1-202
ENSP00000353427
ENST00000360284
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 611 aa
66 kDa 		No 0
NR4A1-203
ENSP00000378302
ENST00000394825
P22736 [Direct mapping]
Nuclear receptor subfamily 4 group A member 1
A0A024R126 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d
Show all
Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
Show all
 598 aa
64.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.