Fields »
ABOUT
HELP
BLOG
LRP1

GENERAL INFORMATION

Gene name

 LRP1

Gene description

 Low density lipoprotein receptor-related protein 1

Protein class

 Candidate cardiovascular disease genes
CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, RH-30, U-87 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in liver, placenta, brain, adipose tissue and in fibroblasts. Also expressed in the tissue stroma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA004182 , HPA022903 , CAB018621
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004182
HPA022903
CAB018621

GENE INFORMATION

Gene name

 LRP1 (HGNC Symbol)

Synonyms

 A2MR, APOER, APR, CD91, LRP, LRP1A

Description

 Low density lipoprotein receptor-related protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57128493 - 57213351

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123384 (version 83.38)

Entrez gene

 4035

UniProt

 Q07954 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07954

Antibodypedia

 LRP1 antibodies

PROTEIN BROWSER
LRP1-001
LRP1-002
LRP1-003
LRP1-004
LRP1-009
LRP1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRP1-001
ENSP00000243077
ENST00000243077
Q07954 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002020 [protease binding]
GO:0004872 [receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007568 [aging]
GO:0007603 [phototransduction, visible light]
GO:0008283 [cell proliferation]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010977 [negative regulation of neuron projection development]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0021987 [cerebral cortex development]
GO:0030136 [clathrin-coated vesicle]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032370 [positive regulation of lipid transport]
GO:0032374 [regulation of cholesterol transport]
GO:0032403 [protein complex binding]
GO:0032429 [regulation of phospholipase A2 activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034185 [apolipoprotein binding]
GO:0035909 [aorta morphogenesis]
GO:0042157 [lipoprotein metabolic process]
GO:0042953 [lipoprotein transport]
GO:0042954 [lipoprotein transporter activity]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0051222 [positive regulation of protein transport]
GO:0070325 [lipoprotein particle receptor binding]
GO:0097242 [beta-amyloid clearance]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 4544 aa
504.6 kDa 		Yes 1
LRP1-002
ENSP00000451449
ENST00000553277
Q7Z7K9 [Direct mapping]
LRP1 protein; Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 296 aa
32.2 kDa 		Yes 0
LRP1-003
ENSP00000341264
ENST00000338962
Q07954 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domain
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0004872 [receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007603 [phototransduction, visible light]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0032370 [positive regulation of lipid transport]
GO:0032374 [regulation of cholesterol transport]
GO:0032403 [protein complex binding]
GO:0032429 [regulation of phospholipase A2 activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034185 [apolipoprotein binding]
GO:0035909 [aorta morphogenesis]
GO:0042953 [lipoprotein transport]
GO:0042954 [lipoprotein transporter activity]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0044822 [poly(A) RNA binding]
GO:0070325 [lipoprotein particle receptor binding]
GO:0097242 [beta-amyloid clearance]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
 292 aa
31.6 kDa 		Yes 0
LRP1-004
ENSP00000451737
ENST00000554174
Q6PJ72 [Direct mapping]
LRP1 protein; Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
Show all
 439 aa
48.2 kDa 		Yes 0
LRP1-009
ENSP00000451012
ENST00000555124
H0YJ88 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 183 aa
20.6 kDa 		No 0
LRP1-012
ENSP00000451622
ENST00000554118
H0YJI8 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 139 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.