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NFE2

GENERAL INFORMATION

Gene name

 NFE2

Gene description

 Nuclear factor, erythroid 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL, K-562, NB-4)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in hematopoietic cells and subsets of immune cells in several tissues including gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA001914
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001914

GENE INFORMATION

Gene name

 NFE2 (HGNC Symbol)

Synonyms

 NF-E2

Description

 Nuclear factor, erythroid 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 54292111 - 54301121

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123405 (version 83.38)

Entrez gene

 4778

UniProt

 Q16621 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16621

Antibodypedia

 NFE2 antibodies

PROTEIN BROWSER
NFE2-001
NFE2-002
NFE2-003
NFE2-004
NFE2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFE2-001
ENSP00000397185
ENST00000435572
Q16621 [Direct mapping]
Transcription factor NF-E2 45 kDa subunit
A8K3E0 [Target identity:100%; Query identity:100%]
Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a; cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNA
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008015 [blood circulation]
GO:0015629 [actin cytoskeleton]
GO:0016605 [PML body]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050699 [WW domain binding]
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 373 aa
41.5 kDa 		No 0
NFE2-002
ENSP00000447558
ENST00000553070
Q16621 [Direct mapping]
Transcription factor NF-E2 45 kDa subunit
A8K3E0 [Target identity:100%; Query identity:100%]
Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a; cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008015 [blood circulation]
GO:0015629 [actin cytoskeleton]
GO:0016605 [PML body]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050699 [WW domain binding]
Show all
 373 aa
41.5 kDa 		No 0
NFE2-003
ENSP00000312436
ENST00000312156
Q16621 [Direct mapping]
Transcription factor NF-E2 45 kDa subunit
A8K3E0 [Target identity:100%; Query identity:100%]
Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a; cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008015 [blood circulation]
GO:0015629 [actin cytoskeleton]
GO:0016605 [PML body]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050699 [WW domain binding]
Show all
 373 aa
41.5 kDa 		No 0
NFE2-004
ENSP00000439120
ENST00000540264
Q16621 [Direct mapping]
Transcription factor NF-E2 45 kDa subunit
A8K3E0 [Target identity:100%; Query identity:100%]
Nuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a; cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein; cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008015 [blood circulation]
GO:0015629 [actin cytoskeleton]
GO:0016605 [PML body]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050699 [WW domain binding]
Show all
 373 aa
41.5 kDa 		No 0
NFE2-005
ENSP00000446929
ENST00000553198
F8W1N9 [Direct mapping]
Transcription factor NF-E2 45 kDa subunit
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0043565 [sequence-specific DNA binding]
Show all
 343 aa
38.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.