Cell atlas - IKZF4 - The Human Protein Atlas

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IKZF4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IKZF4
Gene description	IKAROS family zinc finger 4 (Eos)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies & nucleoplasm.
RNA cell category	Cell line enhanced (HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046270
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (supported), Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046270	CACO-2	Nucleoplasm
	HPA046270	RH-30	Nucleoplasm
	HPA046270	RH-30	Nuclear bodies
	HPA046270	U-2 OS	Nucleoplasm
	HPA046270	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	IKZF4 (HGNC Symbol)
Synonyms	Eos, ZNFN1A4
Description	IKAROS family zinc finger 4 (Eos) (HGNC Symbol)
Entrez gene summary	Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	56007659 - 56038435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123411 (version 83.38)
Entrez gene	64375
UniProt	Q9H2S9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2S9
Antibodypedia	IKZF4 antibodies

PROTEIN BROWSER

IKZF4-001	IKZF4-003	IKZF4-005	IKZF4-011	IKZF4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IKZF4-001 ENSP00000262032 ENST00000262032	Q9H2S9 [Direct mapping] Zinc finger protein Eos Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0042803 [protein homodimerization activity] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	585 aa 64.1 kDa	No	0
IKZF4-003 ENSP00000448419 ENST00000547167	Q9H2S9 [Direct mapping] Zinc finger protein Eos Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	585 aa 64.1 kDa	No	0
IKZF4-005 ENSP00000450020 ENST00000547791	F8VPL6 [Direct mapping] Zinc finger protein Eos Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	540 aa 59.1 kDa	No	0
IKZF4-011 ENSP00000449168 ENST00000552689	A0A0G2JL44 [Direct mapping] Zinc finger protein Eos Show all	Predicted intracellular proteins Show all		10 aa 1.2 kDa	No	0
IKZF4-201 ENSP00000412101 ENST00000431367	Q9H2S9 [Direct mapping] Zinc finger protein Eos Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	585 aa 64.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.