Cell atlas - SARDH - The Human Protein Atlas

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SARDH

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	SARDH
Gene description	Sarcosine dehydrogenase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Group enriched (RPMI-8226, Hep G2, MOLT-4, RH-30, AN3-CA, SH-SY5Y, LHCN-M2)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058086
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPMI-8226, Hep G2, MOLT-4, RH-30, AN3-CA, SH-SY5Y, LHCN-M2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058086	Hep G2	Mitochondria
	HPA058086	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	SARDH (HGNC Symbol)
Synonyms	DMGDHL1, SDH
Description	Sarcosine dehydrogenase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133663560 - 133739955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123453 (version 83.38)
Entrez gene	1757
UniProt	Q9UL12 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL12
Antibodypedia	SARDH antibodies

PROTEIN BROWSER

SARDH-001	SARDH-002	SARDH-004	SARDH-005	SARDH-201	SARDH-202	SARDH-203	SARDH-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SARDH-001 ENSP00000360938 ENST00000371872	Q9UL12 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008480 [sarcosine dehydrogenase activity] GO:0016491 [oxidoreductase activity] GO:0035999 [tetrahydrofolate interconversion] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	918 aa 101 kDa	No	0
SARDH-002 ENSP00000360934 ENST00000371868	Q5SYV2 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		368 aa 40.2 kDa	No	0
SARDH-004 ENSP00000360933 ENST00000371867	Q5SYU9 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	283 aa 31.1 kDa	No	0
SARDH-005 ENSP00000394210 ENST00000427237	Q5SYV1 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	608 aa 67.1 kDa	No	0
SARDH-201 ENSP00000298628 ENST00000298628	Q9UL10 [Direct mapping] Putative uncharacterized protein SARDH; Sarcosine dehydrogenase, isoform CRA_d; Sarcosine dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005759 [mitochondrial matrix] GO:0008150 [biological_process] GO:0008480 [sarcosine dehydrogenase activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	396 aa 42.4 kDa	No	0
SARDH-202 ENSP00000415537 ENST00000422262	A0A0A0MT55 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	602 aa 67.2 kDa	No	0
SARDH-203 ENSP00000403084 ENST00000439388	Q9UL12 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008480 [sarcosine dehydrogenase activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	918 aa 101 kDa	No	0
SARDH-204 ENSP00000484683 ENST00000616662	A0A087X242 [Direct mapping] Sarcosine dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	474 aa 51.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.