Expression of STIL in cancer - Summary - The Human Protein Atlas

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STIL

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	STIL
Gene description	SCL/TAL1 interrupting locus
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	STIL (HGNC Symbol)
Synonyms	MCPH7, SIL
Description	SCL/TAL1 interrupting locus (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	47250139 - 47314147
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123473 (version 83.38)
Entrez gene	6491
UniProt	Q15468 (UniProt - Evidence at protein level)
neXtProt	NX_Q15468
Antibodypedia	STIL antibodies

PROTEIN BROWSER

STIL-001	STIL-002	STIL-004	STIL-005	STIL-006	STIL-008	STIL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STIL-001 ENSP00000353544 ENST00000360380	Q15468 [Direct mapping] SCL-interrupting locus protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000578 [embryonic axis specification] GO:0001701 [in utero embryonic development] GO:0001843 [neural tube closure] GO:0001947 [heart looping] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0007052 [mitotic spindle organization] GO:0007224 [smoothened signaling pathway] GO:0007368 [determination of left/right symmetry] GO:0008283 [cell proliferation] GO:0021915 [neural tube development] GO:0030900 [forebrain development] GO:0030903 [notochord development] GO:0033504 [floor plate development] GO:0035264 [multicellular organism growth] GO:0043066 [negative regulation of apoptotic process] GO:0051298 [centrosome duplication] GO:0071539 [protein localization to centrosome] Show all	1287 aa 143 kDa	No	0
STIL-002 ENSP00000411664 ENST00000447475	Q5T0C7 [Direct mapping] SCL-interrupting locus protein; SCL/TAL1 interrupting locus Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		918 aa 102.2 kDa	No	0
STIL-004 ENSP00000360944 ENST00000371877	Q15468 [Direct mapping] SCL-interrupting locus protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000578 [embryonic axis specification] GO:0001701 [in utero embryonic development] GO:0001843 [neural tube closure] GO:0001947 [heart looping] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0007052 [mitotic spindle organization] GO:0007224 [smoothened signaling pathway] GO:0007368 [determination of left/right symmetry] GO:0008283 [cell proliferation] GO:0021915 [neural tube development] GO:0030900 [forebrain development] GO:0030903 [notochord development] GO:0033504 [floor plate development] GO:0035264 [multicellular organism growth] GO:0043066 [negative regulation of apoptotic process] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051298 [centrosome duplication] GO:0060271 [cilium morphogenesis] GO:0071539 [protein localization to centrosome] Show all	1288 aa 143 kDa	No	0
STIL-005 ENSP00000412019 ENST00000413565	Q5T0C8 [Direct mapping] SCL-interrupting locus protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.6 kDa	No	0
STIL-006 ENSP00000409087 ENST00000436811	H0Y702 [Direct mapping] SCL-interrupting locus protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		211 aa 23 kDa	No	0
STIL-008 ENSP00000379523 ENST00000396221	E9PSF2 [Direct mapping] SCL-interrupting locus protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		1270 aa 141.1 kDa	No	0
STIL-201 ENSP00000337367 ENST00000337817	A0A0A0MR87 [Direct mapping] SCL-interrupting locus protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		1241 aa 137.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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