Expression of AMD1 in cancer - Summary - The Human Protein Atlas

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AMD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMD1
Gene description	Adenosylmethionine decarboxylase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA029281 , HPA029282
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), breast cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Breast cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029281	HPA029282

GENE INFORMATION
Gene name	AMD1 (HGNC Symbol)
Synonyms	SAMDC
Description	Adenosylmethionine decarboxylase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	110814621 - 110895713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123505 (version 83.38)
Entrez gene	262
UniProt	P17707 (UniProt - Evidence at protein level)
neXtProt	NX_P17707
Antibodypedia	AMD1 antibodies

PROTEIN BROWSER

AMD1-002	AMD1-003	AMD1-005	AMD1-201	AMD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMD1-002 ENSP00000357870 ENST00000368876	Q5VXN5 [Direct mapping] S-adenosylmethionine decarboxylase proenzyme; cDNA FLJ59608, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50); cDNA, FLJ79370, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004014 [adenosylmethionine decarboxylase activity] GO:0006597 [spermine biosynthetic process] GO:0008295 [spermidine biosynthetic process] Show all	265 aa 30.5 kDa	No	0
AMD1-003 ENSP00000357880 ENST00000368885	P17707 [Direct mapping] S-adenosylmethionine decarboxylase proenzyme S-adenosylmethionine decarboxylase alpha chain S-adenosylmethionine decarboxylase beta chain Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004014 [adenosylmethionine decarboxylase activity] GO:0005829 [cytosol] GO:0006557 [S-adenosylmethioninamine biosynthetic process] GO:0006595 [polyamine metabolic process] GO:0006597 [spermine biosynthetic process] GO:0008295 [spermidine biosynthetic process] GO:0019810 [putrescine binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046500 [S-adenosylmethionine metabolic process] Show all	334 aa 38.3 kDa	No	0
AMD1-005 ENSP00000357871 ENST00000368877	Q5VXN5 [Direct mapping] S-adenosylmethionine decarboxylase proenzyme; cDNA FLJ59608, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50); cDNA, FLJ79370, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004014 [adenosylmethionine decarboxylase activity] GO:0006597 [spermine biosynthetic process] GO:0008295 [spermidine biosynthetic process] Show all	265 aa 30.5 kDa	No	0
AMD1-201 ENSP00000357877 ENST00000368882	B4DZ60 [Direct mapping] S-adenosylmethionine decarboxylase proenzyme; cDNA FLJ52467, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004014 [adenosylmethionine decarboxylase activity] GO:0006597 [spermine biosynthetic process] GO:0008295 [spermidine biosynthetic process] Show all	214 aa 24.5 kDa	No	0
AMD1-202 ENSP00000483984 ENST00000610605	Q5VXN5 [Direct mapping] S-adenosylmethionine decarboxylase proenzyme; cDNA FLJ59608, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50); cDNA, FLJ79370, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004014 [adenosylmethionine decarboxylase activity] GO:0006597 [spermine biosynthetic process] GO:0008295 [spermidine biosynthetic process] Show all	265 aa 30.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.