Expression of PLP1 in cancer - Summary - The Human Protein Atlas

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PLP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLP1
Gene description	Proteolipid protein 1
Protein class	Cancer-related genes Disease related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma)
HPA (cell line):	Group enriched (NTERA-2, SK-MEL-30, WM-115)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in oligodendrocytes in CNS

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA004128
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004128

GENE INFORMATION
Gene name	PLP1 (HGNC Symbol)
Synonyms	GPM6C, PLP, SPG2
Description	Proteolipid protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Chromosome	X
Cytoband	q22.2
Chromosome location (bp)	103773718 - 103792619
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123560 (version 83.38)
Entrez gene	5354
UniProt	P60201 (UniProt - Evidence at protein level)
neXtProt	NX_P60201
Antibodypedia	PLP1 antibodies

PROTEIN BROWSER

PLP1-001	PLP1-002	PLP1-004	PLP1-005	PLP1-006	PLP1-007	PLP1-008	PLP1-009	PLP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLP1-001 ENSP00000484450 ENST00000621218	P60201 [Direct mapping] Myelin proteolipid protein A8K9L3 [Target identity:100%; Query identity:100%] Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated), isoform CRA_b; cDNA FLJ77822, highly similar to Homo sapiens proteolipid protein 1 (Pelizaeus-Merzbacher disease,spastic paraplegia 2, uncomplicated) (PLP1), mRNA; cDNA, FLJ92659, highly similar to Homo sapiens proteolipid protein 1 (Pelizaeus-Merzbacher disease,spastic paraplegia 2, uncomplicated) (PLP1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0008366 [axon ensheathment] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0043209 [myelin sheath] Show all	277 aa 30.1 kDa	No	4
PLP1-002 ENSP00000477619 ENST00000619236	P60201 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0008366 [axon ensheathment] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0043209 [myelin sheath] Show all	242 aa 26.3 kDa	No	4
PLP1-004 ENSP00000403335 ENST00000434483	B1B1G3 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	123 aa 13.3 kDa	No	2
PLP1-005 ENSP00000480409 ENST00000494475	A0A0E3D6M4 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	137 aa 14.9 kDa	No	2
PLP1-006 ENSP00000409802 ENST00000455268	B1B1G6 [Direct mapping] Myelin proteolipid protein Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	136 aa 14.7 kDa	No	2
PLP1-007 ENSP00000413931 ENST00000422393	B1B1G4 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	127 aa 13.7 kDa	No	2
PLP1-008 ENSP00000393391 ENST00000433491	B1B1G1 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	100 aa 11 kDa	No	2
PLP1-009 ENSP00000391853 ENST00000443502	B1B1G2 [Direct mapping] Myelin proteolipid protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 12.3 kDa	No	2
PLP1-201 ENSP00000481006 ENST00000612423	P60201 [Direct mapping] Myelin proteolipid protein A8K9L3 [Target identity:100%; Query identity:100%] Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated), isoform CRA_b; cDNA FLJ77822, highly similar to Homo sapiens proteolipid protein 1 (Pelizaeus-Merzbacher disease,spastic paraplegia 2, uncomplicated) (PLP1), mRNA; cDNA, FLJ92659, highly similar to Homo sapiens proteolipid protein 1 (Pelizaeus-Merzbacher disease,spastic paraplegia 2, uncomplicated) (PLP1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007229 [integrin-mediated signaling pathway] GO:0007268 [synaptic transmission] GO:0008366 [axon ensheathment] GO:0010001 [glial cell differentiation] GO:0010628 [positive regulation of gene expression] GO:0014002 [astrocyte development] GO:0016021 [integral component of membrane] GO:0019911 [structural constituent of myelin sheath] GO:0021762 [substantia nigra development] GO:0022010 [central nervous system myelination] GO:0042552 [myelination] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0043209 [myelin sheath] GO:0048469 [cell maturation] GO:0061564 [axon development] Show all	277 aa 30.1 kDa	No	4

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The Human Protein Atlas project is funded
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