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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

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Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Score

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Antibodies

Column

 
 
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ACVR1C
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACVR1C

Gene description

Activin A receptor, type IC

Protein class

Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adipose tissue)
GTEx:Tissue enhanced (adipose tissue, breast)
FANTOM5:Tissue enhanced (adipose tissue, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 2 antibodies.
HPA007982 , HPA011933
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, pituitary gland)

GENE INFORMATION

Gene name

ACVR1C (HGNC Symbol)

Synonyms

ACVRLK7, ALK7

Description

Activin A receptor, type IC (HGNC Symbol)

Entrez gene summary

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

q24.1

Chromosome location (bp)

157526767 - 157629005

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123612 (version 83.38)

Entrez gene

130399

UniProt

Q8NER5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NER5

Antibodypedia

ACVR1C antibodies

PROTEIN BROWSER

ACVR1C-001
ACVR1C-002
ACVR1C-003
ACVR1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1C-001
ENSP00000243349
ENST00000243349
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002021 [response to dietary excess]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0019915 [lipid storage]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0032868 [response to insulin]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
493 aa
54.9 kDa
Yes 1
ACVR1C-002
ENSP00000335139
ENST00000348328
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
336 aa
37.5 kDa
Yes 0
ACVR1C-003
ENSP00000335178
ENST00000335450
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
413 aa
46.4 kDa
Yes 0
ACVR1C-004
ENSP00000387168
ENST00000409680
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
443 aa
49.7 kDa
No 1

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