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ACVR1C

GENERAL INFORMATION

Gene name

 ACVR1C

Gene description

 Activin A receptor, type IC

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adipose tissue)
GTEx:Tissue enhanced (adipose tissue, breast)
FANTOM5:Tissue enhanced (adipose tissue, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA007982 , HPA011933
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, pituitary gland)

GENE INFORMATION

Gene name

 ACVR1C (HGNC Symbol)

Synonyms

 ACVRLK7, ALK7

Description

 Activin A receptor, type IC (HGNC Symbol)

Entrez gene summary

 ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q24.1

Chromosome location (bp)

 157526767 - 157629005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123612 (version 83.38)

Entrez gene

 130399

UniProt

 Q8NER5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NER5

Antibodypedia

 ACVR1C antibodies

PROTEIN BROWSER
ACVR1C-001
ACVR1C-002
ACVR1C-003
ACVR1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACVR1C-001
ENSP00000243349
ENST00000243349
Q8NER5 [Direct mapping]
Activin receptor type-1C
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002021 [response to dietary excess]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0019915 [lipid storage]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0032868 [response to insulin]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 493 aa
54.9 kDa 		Yes 1
ACVR1C-002
ENSP00000335139
ENST00000348328
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 336 aa
37.5 kDa 		Yes 0
ACVR1C-003
ENSP00000335178
ENST00000335450
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 413 aa
46.4 kDa 		Yes 0
ACVR1C-004
ENSP00000387168
ENST00000409680
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 443 aa
49.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.