Expression of SLC36A1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC36A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC36A1
Gene description	Solute carrier family 36 (proton/amino acid symporter), member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035937
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035937

GENE INFORMATION
Gene name	SLC36A1 (HGNC Symbol)
Synonyms	LYAAT-1, PAT1, TRAMD3
Description	Solute carrier family 36 (proton/amino acid symporter), member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	151437046 - 151492381
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123643 (version 83.38)
Entrez gene	206358
UniProt	Q7Z2H8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2H8
Antibodypedia	SLC36A1 antibodies

PROTEIN BROWSER

SLC36A1-001	SLC36A1-002	SLC36A1-003	SLC36A1-004	SLC36A1-007	SLC36A1-008	SLC36A1-009	SLC36A1-010	SLC36A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC36A1-001 ENSP00000243389 ENST00000243389	Q7Z2H8 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015824 [proline transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	476 aa 53.1 kDa	No	>9
SLC36A1-002 ENSP00000430305 ENST00000521925	E7EW39 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	388 aa 43.7 kDa	No	8
SLC36A1-003 ENSP00000428738 ENST00000517628	H0YB60 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	145 aa 16.5 kDa	No	3
SLC36A1-004 ENSP00000395640 ENST00000429484	Q7Z2H8 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	243 aa 27.3 kDa	No	6
SLC36A1-007 ENSP00000428140 ENST00000520701	Q7Z2H8 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	476 aa 53.1 kDa	No	>9
SLC36A1-008 ENSP00000429796 ENST00000520111	E5RHG5 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	99 aa 10.6 kDa	No	1
SLC36A1-009 ENSP00000427804 ENST00000517945	E5RG64 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	70 aa 7.7 kDa	No	0
SLC36A1-010 ENSP00000428471 ENST00000519829	E5RI40 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	72 aa 7.9 kDa	No	0
SLC36A1-201 ENSP00000480948 ENST00000616007	Q7Z2H8 [Direct mapping] Proton-coupled amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	386 aa 43.5 kDa	No	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.