Expression of PLA2G12A in cancer - Summary - The Human Protein Atlas

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PLA2G12A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLA2G12A
Gene description	Phospholipase A2, group XIIA
Protein class	Enzymes Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA035908 , HPA035909
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035908	HPA035909

GENE INFORMATION
Gene name	PLA2G12A (HGNC Symbol)
Synonyms	PLA2G12
Description	Phospholipase A2, group XIIA (HGNC Symbol)
Entrez gene summary	Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	109709989 - 109730077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123739 (version 83.38)
Entrez gene	81579
UniProt	Q9BZM1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZM1
Antibodypedia	PLA2G12A antibodies

PROTEIN BROWSER

PLA2G12A-001	PLA2G12A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G12A-001 ENSP00000243501 ENST00000243501	Q9BZM1 [Direct mapping] Group XIIA secretory phospholipase A2 Q542Y6 [Target identity:100%; Query identity:100%] Phospholipase A2, group XIIA, isoform CRA_b; cDNA PSEC0079 fis, clone NT2RP2004049, highly similar to Group XII secretory phospholipase A2 (EC 3.1.1.4); cDNA, FLJ93563, Homo sapiens phospholipase A2, group XII (PLA2G12), mRNA Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004623 [phospholipase A2 activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008150 [biological_process] GO:0016042 [lipid catabolic process] GO:0036148 [phosphatidylglycerol acyl-chain remodeling] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036150 [phosphatidylserine acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047498 [calcium-dependent phospholipase A2 activity] Show all	189 aa 21.1 kDa	Yes	0
PLA2G12A-002 ENSP00000425274 ENST00000502283	A0A0C4DGC6 [Direct mapping] Group XIIA secretory phospholipase A2; Phospholipase A2, group XIIA, isoform CRA_d Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004623 [phospholipase A2 activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0006644 [phospholipid metabolic process] GO:0016042 [lipid catabolic process] Show all	187 aa 20.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.