Expression of ADCK4 in cancer - Summary - The Human Protein Atlas

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ADCK4

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADCK4
Gene description	AarF domain containing kinase 4
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA027229 , HPA027277 , HPA027279
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027229	HPA027277	HPA027279

GENE INFORMATION
Gene name	ADCK4 (HGNC Symbol)
Synonyms	COQ8, FLJ12229
Description	AarF domain containing kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40691529 - 40718207
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123815 (version 83.38)
Entrez gene	79934
UniProt	Q96D53 (UniProt - Evidence at protein level)
neXtProt	NX_Q96D53
Antibodypedia	ADCK4 antibodies

PROTEIN BROWSER

ADCK4-001	ADCK4-002	ADCK4-006	ADCK4-009	ADCK4-010	ADCK4-011	ADCK4-012	ADCK4-013	ADCK4-014	ADCK4-015	ADCK4-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCK4-001 ENSP00000315118 ENST00000324464	Q96D53 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Enzymes Kinases Atypical kinases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	544 aa 60.1 kDa	No	0
ADCK4-002 ENSP00000243583 ENST00000243583	Q96D53 [Direct mapping] AarF domain-containing protein kinase 4 A0A024R0Q9 [Target identity:100%; Query identity:100%] AarF domain containing kinase 4, isoform CRA_b Show all	Enzymes Kinases Atypical kinases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	503 aa 55.9 kDa	No	0
ADCK4-006 ENSP00000471310 ENST00000594490	M0R0L2 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 14.4 kDa	No	0
ADCK4-009 ENSP00000470876 ENST00000594720	M0QZZ2 [Direct mapping] AarF domain-containing protein kinase 4 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 15.8 kDa	No	0
ADCK4-010 ENSP00000472978 ENST00000600707	M0R340 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 12.9 kDa	No	0
ADCK4-011 ENSP00000472775 ENST00000593723	A0A0G2JLJ7 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
ADCK4-012 ENSP00000473189 ENST00000594084	M0R3F7 [Direct mapping] AarF domain-containing protein kinase 4 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 16.5 kDa	No	0
ADCK4-013 ENSP00000472925 ENST00000596357	M0R307 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.8 kDa	No	0
ADCK4-014 ENSP00000470894 ENST00000595254	M0R001 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		204 aa 22.5 kDa	No	0
ADCK4-015 ENSP00000473017 ENST00000600080	M0R362 [Direct mapping] AarF domain-containing protein kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.3 kDa	No	0
ADCK4-018 ENSP00000470916 ENST00000601967	M0R011 [Direct mapping] AarF domain-containing protein kinase 4 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 25 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.