Expression of C4BPB in cancer - Summary - The Human Protein Atlas

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C4BPB

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C4BPB
Gene description	Complement component 4 binding protein, beta
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Group enriched (CACO-2, HeLa, Hep G2)
HPA (normal tissue):	Group enriched (liver, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051620
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051620

GENE INFORMATION
Gene name	C4BPB (HGNC Symbol)
Synonyms	C4BP
Description	Complement component 4 binding protein, beta (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	207088842 - 207099993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123843 (version 83.38)
Entrez gene	725
UniProt	P20851 (UniProt - Evidence at protein level)
neXtProt	NX_P20851
Antibodypedia	C4BPB antibodies

PROTEIN BROWSER

C4BPB-001	C4BPB-002	C4BPB-003	C4BPB-004	C4BPB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C4BPB-001 ENSP00000243611 ENST00000243611	P20851 [Direct mapping] C4b-binding protein beta chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007596 [blood coagulation] GO:0030449 [regulation of complement activation] GO:0044216 [other organism cell] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045959 [negative regulation of complement activation, classical pathway] GO:1903027 [regulation of opsonization] Show all	252 aa 28.4 kDa	Yes	0
C4BPB-002 ENSP00000356043 ENST00000367076	P20851 [Direct mapping] C4b-binding protein beta chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007596 [blood coagulation] GO:0030449 [regulation of complement activation] GO:0044216 [other organism cell] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045959 [negative regulation of complement activation, classical pathway] GO:1903027 [regulation of opsonization] Show all	251 aa 28.3 kDa	Yes	0
C4BPB-003 ENSP00000356045 ENST00000367078	P20851 [Direct mapping] C4b-binding protein beta chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007596 [blood coagulation] GO:0030449 [regulation of complement activation] GO:0044216 [other organism cell] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045959 [negative regulation of complement activation, classical pathway] GO:1903027 [regulation of opsonization] Show all	252 aa 28.4 kDa	Yes	0
C4BPB-004 ENSP00000392237 ENST00000452902	Q5VVQ7 [Direct mapping] C4b-binding protein beta chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 20.3 kDa	Yes	0
C4BPB-201 ENSP00000375790 ENST00000391923	P20851 [Direct mapping] C4b-binding protein beta chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007596 [blood coagulation] GO:0030449 [regulation of complement activation] GO:0044216 [other organism cell] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045959 [negative regulation of complement activation, classical pathway] GO:1903027 [regulation of opsonization] Show all	252 aa 28.4 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.