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AGO2

GENERAL INFORMATION

Gene name

 AGO2

Gene description

 Argonaute RISC catalytic component 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB019309
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AGO2 (HGNC Symbol)

Synonyms

 EIF2C2, hAGO2, Q10

Description

 Argonaute RISC catalytic component 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 140520156 - 140635619

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123908 (version 83.38)

Entrez gene

 27161

UniProt

 Q9UKV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKV8

Antibodypedia

 AGO2 antibodies

PROTEIN BROWSER
AGO2-001
AGO2-002
AGO2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGO2-001
ENSP00000220592
ENST00000220592
Q9UKV8 [Direct mapping]
Protein argonaute-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000993 [RNA polymerase II core binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0005845 [mRNA cap binding complex]
GO:0006351 [transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009791 [post-embryonic development]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0010586 [miRNA metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0030425 [dendrite]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035068 [micro-ribonucleoprotein complex]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035194 [posttranscriptional gene silencing by RNA]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0035279 [mRNA cleavage involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045947 [negative regulation of translational initiation]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0070551 [endoribonuclease activity, cleaving siRNA-paired mRNA]
GO:0070578 [RISC-loading complex]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:0090624 [endoribonuclease activity, cleaving miRNA-paired mRNA]
GO:0090625 [mRNA cleavage involved in gene silencing by siRNA]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
Show all
 859 aa
97.2 kDa 		No 0
AGO2-002
ENSP00000430176
ENST00000519980
Q9UKV8 [Direct mapping]
Protein argonaute-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000993 [RNA polymerase II core binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0005845 [mRNA cap binding complex]
GO:0006351 [transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035068 [micro-ribonucleoprotein complex]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035194 [posttranscriptional gene silencing by RNA]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0035279 [mRNA cleavage involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045947 [negative regulation of translational initiation]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0070551 [endoribonuclease activity, cleaving siRNA-paired mRNA]
GO:0070578 [RISC-loading complex]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:0090624 [endoribonuclease activity, cleaving miRNA-paired mRNA]
GO:0090625 [mRNA cleavage involved in gene silencing by siRNA]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
Show all
 825 aa
93.6 kDa 		No 0
AGO2-006
ENSP00000431056
ENST00000524328
E5RJY2 [Direct mapping]
Protein argonaute-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 36 aa
4.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.