Expression of CKS2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CKS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CKS2
Gene description	CDC28 protein kinase regulatory subunit 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA030762
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030762

GENE INFORMATION
Gene name	CKS2
Synonyms
Description	CDC28 protein kinase regulatory subunit 2 (HGNC Symbol)
Entrez gene summary	CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q22.2
Chromosome location (bp)	89311198 - 89316703
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123975 (version 83.38)
Entrez gene	1164
UniProt	P33552 (UniProt - Evidence at protein level)
neXtProt	NX_P33552
Antibodypedia	CKS2 antibodies

PROTEIN BROWSER

CKS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKS2-001 ENSP00000364976 ENST00000314355	P33552 [Direct mapping] Cyclin-dependent kinases regulatory subunit 2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0007049 [cell cycle] GO:0007127 [meiosis I] GO:0008283 [cell proliferation] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0051301 [cell division] Show all	79 aa 9.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.