Expression of ACSL3 in cancer - Summary - The Human Protein Atlas

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ACSL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSL3
Gene description	Acyl-CoA synthetase long-chain family member 3
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA011315
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011315

GENE INFORMATION
Gene name	ACSL3 (HGNC Symbol)
Synonyms	ACS3, FACL3, PRO2194
Description	Acyl-CoA synthetase long-chain family member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	222860934 - 222944639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123983 (version 83.38)
Entrez gene	2181
UniProt	O95573 (UniProt - Evidence at protein level)
neXtProt	NX_O95573
Antibodypedia	ACSL3 antibodies

PROTEIN BROWSER

ACSL3-001	ACSL3-002	ACSL3-003	ACSL3-010	ACSL3-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSL3-001 ENSP00000350012 ENST00000357430	O95573 [Direct mapping] Long-chain-fatty-acid--CoA ligase 3 A0A024R497 [Target identity:100%; Query identity:100%] Acyl-CoA synthetase long-chain family member 3, isoform CRA_a Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0006633 [fatty acid biosynthetic process] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042998 [positive regulation of Golgi to plasma membrane protein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0048471 [perinuclear region of cytoplasm] GO:0051047 [positive regulation of secretion] GO:2001247 [positive regulation of phosphatidylcholine biosynthetic process] Show all	720 aa 80.4 kDa	No	3
ACSL3-002 ENSP00000375918 ENST00000392066	O95573 [Direct mapping] Long-chain-fatty-acid--CoA ligase 3 A0A024R497 [Target identity:100%; Query identity:100%] Acyl-CoA synthetase long-chain family member 3, isoform CRA_a Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042998 [positive regulation of Golgi to plasma membrane protein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0048471 [perinuclear region of cytoplasm] GO:0051047 [positive regulation of secretion] GO:2001247 [positive regulation of phosphatidylcholine biosynthetic process] Show all	720 aa 80.4 kDa	No	3
ACSL3-003 ENSP00000416913 ENST00000413316	C9JC11 [Direct mapping] Long-chain-fatty-acid--CoA ligase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	88 aa 10.1 kDa	No	1
ACSL3-010 ENSP00000438342 ENST00000535678	F5H062 [Direct mapping] Long-chain-fatty-acid--CoA ligase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	95 aa 10.9 kDa	No	1
ACSL3-012 ENSP00000441643 ENST00000540115	F5GWH2 [Direct mapping] Long-chain-fatty-acid--CoA ligase 3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	141 aa 15.4 kDa	No	0

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