We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ACSL3
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACSL3

Gene description

Acyl-CoA synthetase long-chain family member 3

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA011315
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA011315

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed moderate to strong cytoplasmic immunoreactivity. Malignant gliomas were weakly stained or negative.

GENE INFORMATION

Gene name

ACSL3 (HGNC Symbol)

Synonyms

ACS3, FACL3, PRO2194

Description

Acyl-CoA synthetase long-chain family member 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q36.1

Chromosome location (bp)

222860934 - 222944639

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123983 (version 83.38)

Entrez gene

2181

UniProt

O95573 (UniProt - Evidence at protein level)

neXtProt

NX_O95573

Antibodypedia

ACSL3 antibodies

PROTEIN BROWSER

ACSL3-001
ACSL3-002
ACSL3-003
ACSL3-010
ACSL3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACSL3-001
ENSP00000350012
ENST00000357430
O95573 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 3
A0A024R497 [Target identity:100%; Query identity:100%]
Acyl-CoA synthetase long-chain family member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0006633 [fatty acid biosynthetic process]
GO:0007420 [brain development]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0042998 [positive regulation of Golgi to plasma membrane protein transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051047 [positive regulation of secretion]
GO:2001247 [positive regulation of phosphatidylcholine biosynthetic process]
Show all
720 aa
80.4 kDa
No 3
ACSL3-002
ENSP00000375918
ENST00000392066
O95573 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 3
A0A024R497 [Target identity:100%; Query identity:100%]
Acyl-CoA synthetase long-chain family member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0042998 [positive regulation of Golgi to plasma membrane protein transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051047 [positive regulation of secretion]
GO:2001247 [positive regulation of phosphatidylcholine biosynthetic process]
Show all
720 aa
80.4 kDa
No 3
ACSL3-003
ENSP00000416913
ENST00000413316
C9JC11 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
88 aa
10.1 kDa
No 1
ACSL3-010
ENSP00000438342
ENST00000535678
F5H062 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
95 aa
10.9 kDa
No 1
ACSL3-012
ENSP00000441643
ENST00000540115
F5GWH2 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 3
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
141 aa
15.4 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.