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MOGAT1

GENERAL INFORMATION

Gene name

 MOGAT1

Gene description

 Monoacylglycerol O-acyltransferase 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (pancreatic cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (gallbladder)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA049944
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049944

GENE INFORMATION

Gene name

 MOGAT1 (HGNC Symbol)

Synonyms

 DGAT2L, DGAT2L1, MGAT1

Description

 Monoacylglycerol O-acyltransferase 1 (HGNC Symbol)

Entrez gene summary

 Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 222671786 - 222709930

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000124003 (version 83.38)

Entrez gene

 116255

UniProt

 Q96PD6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96PD6

Antibodypedia

 MOGAT1 antibodies

PROTEIN BROWSER
MOGAT1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOGAT1-001
ENSP00000406674
ENST00000446656
Q96PD6 [Direct mapping]
2-acylglycerol O-acyltransferase 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0003846 [2-acylglycerol O-acyltransferase activity]
GO:0004144 [diacylglycerol O-acyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006071 [glycerol metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019432 [triglyceride biosynthetic process]
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 335 aa
38.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.