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SLC12A4

GENERAL INFORMATION

Gene name

 SLC12A4

Gene description

 Solute carrier family 12 (potassium/chloride transporter), member 4

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA041138
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041138

GENE INFORMATION

Gene name

 SLC12A4 (HGNC Symbol)

Synonyms

 KCC1

Description

 Solute carrier family 12 (potassium/chloride transporter), member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67943474 - 67969601

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124067 (version 83.38)

Entrez gene

 6560

UniProt

 Q9UP95 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UP95

Antibodypedia

 SLC12A4 antibodies

PROTEIN BROWSER
SLC12A4-001
SLC12A4-004
SLC12A4-005
SLC12A4-007
SLC12A4-008
SLC12A4-017
SLC12A4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC12A4-001
ENSP00000318557
ENST00000316341
Q9UP95 [Direct mapping]
Solute carrier family 12 member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1085 aa
120.6 kDa 		No >9
SLC12A4-004
ENSP00000438334
ENST00000541864
Q9UP95 [Direct mapping]
Solute carrier family 12 member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1054 aa
117 kDa 		No >9
SLC12A4-005
ENSP00000445962
ENST00000537830
Q9UP95 [Direct mapping]
Solute carrier family 12 member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1079 aa
119.6 kDa 		No >9
SLC12A4-007
ENSP00000461403
ENST00000572037
I3L4N6 [Direct mapping]
Solute carrier family 12 member 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1037 aa
115.1 kDa 		No >9
SLC12A4-008
ENSP00000464168
ENST00000571299
J3QRE2 [Direct mapping]
Solute carrier family 12 member 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 178 aa
18.8 kDa 		No 6
SLC12A4-017
ENSP00000458902
ENST00000576616
Q9UP95 [Direct mapping]
Solute carrier family 12 member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1068 aa
118.6 kDa 		No >9
SLC12A4-201
ENSP00000395983
ENST00000422611
Q9UP95 [Direct mapping]
Solute carrier family 12 member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1087 aa
119.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.