Tissue expression of KCNS1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNS1
Gene description	Potassium voltage-gated channel, modifier subfamily S, member 1
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, gallbladder, seminal vesicle)
GTEx:	Tissue enriched (cerebral cortex)
FANTOM5:	Tissue enhanced (brain, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, gallbladder, seminal vesicle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION
Gene name	KCNS1 (HGNC Symbol)
Synonyms	Kv9.1
Description	Potassium voltage-gated channel, modifier subfamily S, member 1 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45092310 - 45101112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124134 (version 83.38)
Entrez gene	3787
UniProt	Q96KK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KK3
Antibodypedia	KCNS1 antibodies

PROTEIN BROWSER

KCNS1-001	KCNS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNS1-001 ENSP00000307694 ENST00000306117	Q96KK3 [Direct mapping] Potassium voltage-gated channel subfamily S member 1 A2RUL8 [Target identity:100%; Query identity:100%] KCNS1 protein; Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, isoform CRA_b; cDNA FLJ75995, highly similar to Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (KCNS1), mRNA Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:1902259 [regulation of delayed rectifier potassium channel activity] Show all	526 aa 58.4 kDa	No	5
KCNS1-201 ENSP00000445595 ENST00000537075	Q96KK3 [Direct mapping] Potassium voltage-gated channel subfamily S member 1 A2RUL8 [Target identity:100%; Query identity:100%] KCNS1 protein; Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, isoform CRA_b; cDNA FLJ75995, highly similar to Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (KCNS1), mRNA Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:1902259 [regulation of delayed rectifier potassium channel activity] Show all	526 aa 58.4 kDa	No	5