Expression of SLC12A5 in cancer - Summary - The Human Protein Atlas

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SLC12A5

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC12A5
Gene description	Solute carrier family 12 (potassium/chloride transporter), member 5
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (NB-4, U-2 OS)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA072058
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA072058

GENE INFORMATION
Gene name	SLC12A5 (HGNC Symbol)
Synonyms	KCC2, KIAA1176
Description	Solute carrier family 12 (potassium/chloride transporter), member 5 (HGNC Symbol)
Entrez gene summary	K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	46021690 - 46060152
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124140 (version 83.38)
Entrez gene	57468
UniProt	Q9H2X9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2X9
Antibodypedia	SLC12A5 antibodies

PROTEIN BROWSER

SLC12A5-002	SLC12A5-003	SLC12A5-005	SLC12A5-008	SLC12A5-009	SLC12A5-010	SLC12A5-012	SLC12A5-020	SLC12A5-201	SLC12A5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC12A5-002 ENSP00000243964 ENST00000243964	Q9H2X9 [Direct mapping] Solute carrier family 12 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006873 [cellular ion homeostasis] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1116 aa 123.5 kDa	No	>9
SLC12A5-003 ENSP00000387694 ENST00000454036	Q9H2X9 [Direct mapping] Solute carrier family 12 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006873 [cellular ion homeostasis] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0007612 [learning] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035264 [multicellular organism growth] GO:0040040 [thermosensory behavior] GO:0042493 [response to drug] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1139 aa 126.2 kDa	No	>9
SLC12A5-005 ENSP00000476885 ENST00000608944	V9GYL3 [Direct mapping] Solute carrier family 12 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	123 aa 13.3 kDa	No	2
SLC12A5-008 ENSP00000487291 ENST00000413737	A0A0D9SGA5 [Direct mapping] Solute carrier family 12 member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 6 kDa	No	0
SLC12A5-009 ENSP00000487372 ENST00000626701	A0A0D9SGD0 [Direct mapping] HCG1821261; Solute carrier family 12 member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 11.6 kDa	No	0
SLC12A5-010 ENSP00000486382 ENST00000628272	A0A0D9SF89 [Direct mapping] Solute carrier family 12 member 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.8 kDa	No	0
SLC12A5-012 ENSP00000485953 ENST00000626937	M4PNC0 [Direct mapping] KCC2 transcript variant 8; Solute carrier family 12 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	180 aa 19.5 kDa	No	2
SLC12A5-020 ENSP00000478369 ENST00000616202	M4PM71 [Direct mapping] KCC2 transcript variant 7; Solute carrier family 12 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	289 aa 31.1 kDa	No	3
SLC12A5-201 ENSP00000484585 ENST00000616201	A0A087X201 [Direct mapping] Solute carrier family 12 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	459 aa 49.4 kDa	No	6
SLC12A5-202 ENSP00000477569 ENST00000616933	M4PNB5 [Direct mapping] KCC2 transcript variant 3; Solute carrier family 12 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	262 aa 28.1 kDa	No	3

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The Human Protein Atlas

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