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SEMG2

GENERAL INFORMATION

Gene name

 SEMG2

Gene description

 Semenogelin II

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in seminal vesicle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042767 , HPA042835
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042767
HPA042835

GENE INFORMATION

Gene name

 SEMG2 (HGNC Symbol)

Synonyms

 SGII

Description

 Semenogelin II (HGNC Symbol)

Entrez gene summary

 The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45221300 - 45224458

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124157 (version 83.38)

Entrez gene

 6407

UniProt

 Q02383 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02383

Antibodypedia

 SEMG2 antibodies

PROTEIN BROWSER
SEMG2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEMG2-001
ENSP00000361855
ENST00000372769
Q02383 [Direct mapping]
Semenogelin-2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002020 [protease binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0019731 [antibacterial humoral response]
GO:0019953 [sexual reproduction]
GO:0030141 [secretory granule]
GO:0046872 [metal ion binding]
GO:0050817 [coagulation]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:1900005 [positive regulation of serine-type endopeptidase activity]
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 582 aa
65.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.