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PARD6B

GENERAL INFORMATION

Gene name

 PARD6B

Gene description

 Par-6 family cell polarity regulator beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, MCF7, T-47d)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA013376
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (favourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013376

GENE INFORMATION

Gene name

 PARD6B (HGNC Symbol)

Synonyms

 PAR-6B

Description

 Par-6 family cell polarity regulator beta (HGNC Symbol)

Entrez gene summary

 This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 50731544 - 50756795

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124171 (version 83.38)

Entrez gene

 84612

UniProt

 Q9BYG5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYG5

Antibodypedia

 PARD6B antibodies

PROTEIN BROWSER
PARD6B-001
PARD6B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARD6B-001
ENSP00000360672
ENST00000371610
Q9BYG5 [Direct mapping]
Partitioning defective 6 homolog beta
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0007043 [cell-cell junction assembly]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007409 [axonogenesis]
GO:0030334 [regulation of cell migration]
GO:0034329 [cell junction assembly]
GO:0043234 [protein complex]
GO:0045177 [apical part of cell]
GO:0045216 [cell-cell junction organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
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 372 aa
41.2 kDa 		No 0
PARD6B-002
ENSP00000379354
ENST00000396039
Q9BYG5 [Direct mapping]
Partitioning defective 6 homolog beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0007043 [cell-cell junction assembly]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007409 [axonogenesis]
GO:0030334 [regulation of cell migration]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
Show all
 115 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.