Cell atlas - CHD6 - The Human Protein Atlas

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CHD6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CHD6
Gene description	Chromodomain helicase DNA binding protein 6
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA015543
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015543	RH-30	Nucleus
	HPA015543	SiHa	Nucleoplasm
	HPA015543	U-2 OS	No staining

GENE INFORMATION
Gene name	CHD6 (HGNC Symbol)
Synonyms	CHD5, dJ620E11.1, FLJ22369, KIAA1335, RIGB
Description	Chromodomain helicase DNA binding protein 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q12
Chromosome location (bp)	41402101 - 41618494
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124177 (version 83.38)
Entrez gene	84181
UniProt	Q8TD26 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD26
Antibodypedia	CHD6 antibodies

PROTEIN BROWSER

CHD6-001	CHD6-002	CHD6-006	CHD6-008	CHD6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHD6-001 ENSP00000362330 ENST00000373233	Q8TD26 [Direct mapping] Chromodomain-helicase-DNA-binding protein 6 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001221 [transcription cofactor binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0008026 [ATP-dependent helicase activity] GO:0008094 [DNA-dependent ATPase activity] GO:0016568 [chromatin modification] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress] Show all	2715 aa 305.4 kDa	No	0
CHD6-002 ENSP00000404637 ENST00000440697	H7C294 [Direct mapping] Chromodomain-helicase-DNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005634 [nucleus] Show all	525 aa 61.4 kDa	No	0
CHD6-006 ENSP00000362319 ENST00000373222	Q8TD26 [Direct mapping] Chromodomain-helicase-DNA-binding protein 6 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001221 [transcription cofactor binding] GO:0003677 [DNA binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0008026 [ATP-dependent helicase activity] GO:0008094 [DNA-dependent ATPase activity] GO:0016568 [chromatin modification] GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress] Show all	373 aa 41.7 kDa	No	0
CHD6-008 ENSP00000392503 ENST00000440647	A0A075B6P4 [Direct mapping] Chromodomain-helicase-DNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.9 kDa	No	0
CHD6-201 ENSP00000308684 ENST00000309279	C9JFU2 [Direct mapping] Chromodomain-helicase-DNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005634 [nucleus] Show all	488 aa 57.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.