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Cancer cells generally displayed weak to moderate cytoplasmic staining. Several cases of stomach cancers showed strong staining. A majority of lymphomas were negative.
Most cancer cells displayed moderate to strong cytoplasmic positivity. Additional nuclear and/or membranous staining was observed in several cases. A majority of the cases in renal, liver and cervical cancers were weakly stained or negative.
Cancer cells showed moderate to strong cytoplasmic staining which often had a granular pattern or concentrated to large dots.
GENE INFORMATION
Gene name
PLCG1 (HGNC Symbol)
Synonyms
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Description
Phospholipase C, gamma 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)