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EDN3

GENERAL INFORMATION

Gene name

 EDN3

Gene description

 Endothelin 3

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable).
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 EDN3 (HGNC Symbol)

Synonyms

 ET3

Description

 Endothelin 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 59300427 - 59325992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124205 (version 83.38)

Entrez gene

 1908

UniProt

 P14138 (UniProt - Evidence at protein level)

neXtProt

 NX_P14138

Antibodypedia

 EDN3 antibodies

PROTEIN BROWSER
EDN3-001
EDN3-002
EDN3-003
EDN3-004
EDN3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EDN3-001
ENSP00000337128
ENST00000337938
P14138 [Direct mapping]
Endothelin-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001755 [neural crest cell migration]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010460 [positive regulation of heart rate]
GO:0010468 [regulation of gene expression]
GO:0010961 [cellular magnesium ion homeostasis]
GO:0014826 [vein smooth muscle contraction]
GO:0019229 [regulation of vasoconstriction]
GO:0030072 [peptide hormone secretion]
GO:0030182 [neuron differentiation]
GO:0030318 [melanocyte differentiation]
GO:0030334 [regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0031708 [endothelin B receptor binding]
GO:0042310 [vasoconstriction]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046887 [positive regulation of hormone secretion]
GO:0048016 [inositol phosphate-mediated signaling]
GO:0048070 [regulation of developmental pigmentation]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
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 238 aa
25.5 kDa 		Yes 0
EDN3-002
ENSP00000311854
ENST00000311585
P14138 [Direct mapping]
Endothelin-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010460 [positive regulation of heart rate]
GO:0010468 [regulation of gene expression]
GO:0014826 [vein smooth muscle contraction]
GO:0019229 [regulation of vasoconstriction]
GO:0030072 [peptide hormone secretion]
GO:0030593 [neutrophil chemotaxis]
GO:0031708 [endothelin B receptor binding]
GO:0042310 [vasoconstriction]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046887 [positive regulation of hormone secretion]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 219 aa
23.6 kDa 		Yes 0
EDN3-003
ENSP00000379015
ENST00000395654
P14138 [Direct mapping]
Endothelin-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010460 [positive regulation of heart rate]
GO:0010468 [regulation of gene expression]
GO:0014826 [vein smooth muscle contraction]
GO:0019229 [regulation of vasoconstriction]
GO:0030072 [peptide hormone secretion]
GO:0030593 [neutrophil chemotaxis]
GO:0031708 [endothelin B receptor binding]
GO:0042310 [vasoconstriction]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046887 [positive regulation of hormone secretion]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 224 aa
23.9 kDa 		Yes 0
EDN3-004
ENSP00000360064
ENST00000371025
Q4FAT2 [Direct mapping]
Endothelin 3; Endothelin-3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0019229 [regulation of vasoconstriction]
Show all
 192 aa
20.6 kDa 		Yes 0
EDN3-201
ENSP00000360067
ENST00000371028
P14138 [Direct mapping]
Endothelin-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010460 [positive regulation of heart rate]
GO:0010468 [regulation of gene expression]
GO:0014826 [vein smooth muscle contraction]
GO:0019229 [regulation of vasoconstriction]
GO:0030072 [peptide hormone secretion]
GO:0030593 [neutrophil chemotaxis]
GO:0031708 [endothelin B receptor binding]
GO:0042310 [vasoconstriction]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046887 [positive regulation of hormone secretion]
GO:0048016 [inositol phosphate-mediated signaling]
Show all
 238 aa
25.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.