Cell atlas - CSE1L - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CSE1L
Gene description	CSE1 chromosome segregation 1-like (yeast)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA038059 , HPA038060
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA038059	A-431	Nucleoplasm	Intensity
HPA038059	A-431	Cytosol
HPA038059	CACO-2	Nucleoplasm	Intensity
HPA038059	CACO-2	Cytosol
HPA038059	U-2 OS	Nucleoplasm	Intensity
HPA038059	U-2 OS	Cytosol
HPA038060	A-431	Nucleoplasm	Intensity
HPA038060	A-431	Cytosol
HPA038060	CACO-2	Nucleoplasm	Intensity
HPA038060	CACO-2	Cytosol
HPA038060	U-2 OS	Nucleoplasm	Intensity
HPA038060	U-2 OS	Cytosol

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000002718 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038059	NIH 3T3	Nucleoplasm
HPA038059	NIH 3T3	Cytosol
HPA038060	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	CSE1L (HGNC Symbol)
Synonyms	CAS, CSE1, XPO2
Description	CSE1 chromosome segregation 1-like (yeast) (HGNC Symbol)
Entrez gene summary	Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49046246 - 49096960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124207 (version 83.38)
Entrez gene	1434
UniProt	P55060 (UniProt - Evidence at protein level)
neXtProt	NX_P55060
Antibodypedia	CSE1L antibodies

PROTEIN BROWSER

CSE1L-001	CSE1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSE1L-001 ENSP00000262982 ENST00000262982	P55060 [Direct mapping] Exportin-2 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005049 [nuclear export signal receptor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008536 [Ran GTPase binding] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	971 aa 110.4 kDa	No	0
CSE1L-201 ENSP00000379495 ENST00000396192	P55060 [Direct mapping] Exportin-2 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005049 [nuclear export signal receptor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008536 [Ran GTPase binding] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	915 aa 103.9 kDa	No	0