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STX16

GENERAL INFORMATION

Gene name

 STX16

Gene description

 Syntaxin 16

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA041019 , HPA042033
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041019
HPA042033

GENE INFORMATION

Gene name

 STX16 (HGNC Symbol)

Synonyms

 hsyn16, SYN16

Description

 Syntaxin 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 58651253 - 58679526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124222 (version 83.38)

Entrez gene

 8675

UniProt

 O14662 (UniProt - Evidence at protein level)

neXtProt

 NX_O14662

Antibodypedia

 STX16 antibodies

PROTEIN BROWSER
«
STX16-001
STX16-002
STX16-004
STX16-010
STX16-016
STX16-018
STX16-019
STX16-020
STX16-021
STX16-201
STX16-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STX16-001
ENSP00000360173
ENST00000371132
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 304 aa
34.8 kDa 		No 1
STX16-002
ENSP00000360183
ENST00000371141
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 325 aa
37 kDa 		No 1
STX16-004
ENSP00000348229
ENST00000355957
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 308 aa
35.3 kDa 		No 1
STX16-010
ENSP00000350723
ENST00000358029
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 321 aa
36.5 kDa 		No 1
STX16-016
ENSP00000312086
ENST00000312283
F8W9Z6 [Direct mapping]
Syntaxin-16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
Show all
 204 aa
23.3 kDa 		No 0
STX16-018
ENSP00000352634
ENST00000359617
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 272 aa
31.1 kDa 		No 1
STX16-019
ENSP00000388348
ENST00000458280
B7ZBM5 [Direct mapping]
Syntaxin-16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
Show all
 122 aa
13.5 kDa 		No 0
STX16-020
ENSP00000416852
ENST00000412911
B7ZBM4 [Direct mapping]
Syntaxin-16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
Show all
 121 aa
13.4 kDa 		No 0
STX16-021
ENSP00000401801
ENST00000438253
B7ZBM8 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
Show all
 219 aa
25 kDa 		No 1
STX16-201
ENSP00000355408
ENST00000361770
C9K0W8 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
Show all
 307 aa
35.1 kDa 		No 1
STX16-202
ENSP00000354445
ENST00000361830
O14662 [Direct mapping]
Syntaxin-16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006906 [vesicle fusion]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031985 [Golgi cisterna]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048278 [vesicle docking]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090161 [Golgi ribbon formation]
Show all
 272 aa
31.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.