Tissue expression of PMEPA1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PMEPA1
Gene description	Prostate transmembrane protein, androgen induced 1
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine, prostate)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine, prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PMEPA1 (HGNC Symbol)
Synonyms	STAG1, TMEPAI
Description	Prostate transmembrane protein, androgen induced 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	20
Cytoband	q13.31
Chromosome location (bp)	57648392 - 57711536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124225 (version 83.38)
Entrez gene	56937
UniProt	Q969W9 (UniProt - Evidence at protein level)
neXtProt	NX_Q969W9
Antibodypedia	PMEPA1 antibodies

PROTEIN BROWSER

PMEPA1-001	PMEPA1-002	PMEPA1-004	PMEPA1-005	PMEPA1-006	PMEPA1-007	PMEPA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PMEPA1-001 ENSP00000345826 ENST00000341744	Q969W9 [Direct mapping] Protein TMEPAI Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010008 [endosome membrane] GO:0010991 [negative regulation of SMAD protein complex assembly] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0050699 [WW domain binding] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412 [R-SMAD binding] Show all	287 aa 31.6 kDa	No	1
PMEPA1-002 ENSP00000344014 ENST00000347215	Q969W9 [Direct mapping] Protein TMEPAI Q5JY37 [Target identity:100%; Query identity:100%] Transmembrane, prostate androgen induced RNA, isoform CRA_c; cDNA FLJ55980, highly similar to Transmembrane prostate androgen-induced protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010008 [endosome membrane] GO:0010991 [negative regulation of SMAD protein complex assembly] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0050699 [WW domain binding] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412 [R-SMAD binding] Show all	252 aa 27.9 kDa	No	0
PMEPA1-004 ENSP00000379164 ENST00000395819	A2A2F5 [Direct mapping] Protein TMEPAI Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	227 aa 25.4 kDa	No	1
PMEPA1-005 ENSP00000401506 ENST00000414037	A2A2F4 [Direct mapping] Protein TMEPAI Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	208 aa 23 kDa	No	0
PMEPA1-006 ENSP00000379159 ENST00000395814	Q969W9 [Direct mapping] Protein TMEPAI Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010008 [endosome membrane] GO:0010991 [negative regulation of SMAD protein complex assembly] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0050699 [WW domain binding] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412 [R-SMAD binding] Show all	237 aa 26.2 kDa	Yes	0
PMEPA1-007 ENSP00000379161 ENST00000395816	Q969W9 [Direct mapping] Protein TMEPAI Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010008 [endosome membrane] GO:0010991 [negative regulation of SMAD protein complex assembly] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0050699 [WW domain binding] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412 [R-SMAD binding] Show all	237 aa 26.2 kDa	Yes	0
PMEPA1-201 ENSP00000265626 ENST00000265626	Q969W9 [Direct mapping] Protein TMEPAI Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010008 [endosome membrane] GO:0010991 [negative regulation of SMAD protein complex assembly] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0050699 [WW domain binding] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412 [R-SMAD binding] Show all	237 aa 26.2 kDa	Yes	0