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SEMG1

GENERAL INFORMATION

Gene name

 SEMG1

Gene description

 Semenogelin I

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (seminal vesicle)
GTEx:Tissue enriched (prostate)
FANTOM5:Tissue enriched (seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and extracellular expression in seminal vesicle.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA042476
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Seminal vesicle

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (seminal vesicle)

GENE INFORMATION

Gene name

 SEMG1 (HGNC Symbol)

Synonyms

 CT103, SEMG

Description

 Semenogelin I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. The antimicrobial peptide SgI-29 is an antimicrobial peptide with antibacterial activity. [provided by RefSeq, Nov 2014]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45206997 - 45209772

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124233 (version 83.38)

Entrez gene

 6406

UniProt

 P04279 (UniProt - Evidence at protein level)

neXtProt

 NX_P04279

Antibodypedia

 SEMG1 antibodies

PROTEIN BROWSER
SEMG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEMG1-001
ENSP00000361867
ENST00000372781
P04279 [Direct mapping]
Semenogelin-1 Alpha-inhibin-92 Alpha-inhibin-31 Seminal basic protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007320 [insemination]
GO:0019731 [antibacterial humoral response]
GO:0019953 [sexual reproduction]
GO:0030141 [secretory granule]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0050817 [coagulation]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:0090281 [negative regulation of calcium ion import]
GO:1900005 [positive regulation of serine-type endopeptidase activity]
GO:1901318 [negative regulation of sperm motility]
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 462 aa
52.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.