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This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Lyases Predicted intracellular proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006107 [oxaloacetate metabolic process] GO:0006475 [internal protein amino acid acetylation] GO:0006629 [lipid metabolic process] GO:0014823 [response to activity] GO:0017076 [purine nucleotide binding] GO:0017144 [drug metabolic process] GO:0019003 [GDP binding] GO:0030145 [manganese ion binding] GO:0031406 [carboxylic acid binding] GO:0032868 [response to insulin] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0046327 [glycerol biosynthetic process from pyruvate] GO:0051365 [cellular response to potassium ion starvation] GO:0061402 [positive regulation of transcription from RNA polymerase II promoter in response to acidic pH] GO:0070062 [extracellular exosome]
