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MTRR

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GENERAL INFORMATION

Gene name

 MTRR

Gene description

 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & intermediate filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Intermediate filaments (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA038113
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & intermediate filaments.

Main location

 Nucleoplasm (approved)

Additional location

 Intermediate filaments (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038113 A-431 Nucleoplasm
Intermediate filaments
Cytosol
HPA038113 U-2 OS Nucleoplasm
Intermediate filaments
Cytosol
HPA038113 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 MTRR (HGNC Symbol)

Synonyms

 cblE

Description

 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (HGNC Symbol)

Entrez gene summary

 Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 7851186 - 7906025

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124275 (version 83.38)

Entrez gene

 4552

UniProt

 Q9UBK8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBK8

Antibodypedia

 MTRR antibodies

PROTEIN BROWSER
MTRR-001
MTRR-009
MTRR-010
MTRR-012
MTRR-013
MTRR-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTRR-001
ENSP00000264668
ENST00000264668
Q9UBK8 [Direct mapping]
Methionine synthase reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006555 [methionine metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009086 [methionine biosynthetic process]
GO:0009235 [cobalamin metabolic process]
GO:0010181 [FMN binding]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0016723 [oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor]
GO:0030586 [[methionine synthase] reductase activity]
GO:0032259 [methylation]
GO:0033353 [S-adenosylmethionine cycle]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043418 [homocysteine catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046655 [folic acid metabolic process]
GO:0050444 [aquacobalamin reductase (NADPH) activity]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
GO:0071949 [FAD binding]
GO:1904042 [negative regulation of cystathionine beta-synthase activity]
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 725 aa
80.4 kDa 		No 0
MTRR-009
ENSP00000402510
ENST00000440940
Q9UBK8 [Direct mapping]
Methionine synthase reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006555 [methionine metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009086 [methionine biosynthetic process]
GO:0009235 [cobalamin metabolic process]
GO:0010181 [FMN binding]
GO:0016491 [oxidoreductase activity]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0016723 [oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor]
GO:0030586 [[methionine synthase] reductase activity]
GO:0032259 [methylation]
GO:0033353 [S-adenosylmethionine cycle]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043418 [homocysteine catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046655 [folic acid metabolic process]
GO:0050444 [aquacobalamin reductase (NADPH) activity]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
GO:0071949 [FAD binding]
GO:1904042 [negative regulation of cystathionine beta-synthase activity]
Show all
 698 aa
77.7 kDa 		No 0
MTRR-010
ENSP00000423863
ENST00000514220
H0Y9D5 [Direct mapping]
Methionine synthase reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010181 [FMN binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 160 aa
17.6 kDa 		No 0
MTRR-012
ENSP00000424599
ENST00000502550
D6RAZ2 [Direct mapping]
Methionine synthase reductase
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0010181 [FMN binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 156 aa
17.5 kDa 		No 0
MTRR-013
ENSP00000427416
ENST00000506877
D6RIS8 [Direct mapping]
Methionine synthase reductase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010181 [FMN binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 41 aa
4.6 kDa 		Yes 0
MTRR-014
ENSP00000421318
ENST00000512217
D6RGC7 [Direct mapping]
Methionine synthase reductase
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0010181 [FMN binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 112 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.