Expression of IL9R in cancer - Summary - The Human Protein Atlas

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IL9R

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL9R
Gene description	Interleukin 9 receptor
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No internal RNA expression data available for correlation.
Reliability score	Uncertain based on 1 antibody. CAB010497
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB010497

GENE INFORMATION
Gene name	IL9R (HGNC Symbol)
Synonyms	CD129
Description	Interleukin 9 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	155997581 - 156010817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124334 (version 83.38)
Entrez gene	3581
UniProt	Q01113 (UniProt - Evidence at transcript level)
neXtProt	NX_Q01113
Antibodypedia	IL9R antibodies

PROTEIN BROWSER

IL9R-001	IL9R-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL9R-001 ENSP00000358431 ENST00000369423	Q01113 [Direct mapping] Interleukin-9 receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004919 [interleukin-9 receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0038113 [interleukin-9-mediated signaling pathway] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	342 aa 37.4 kDa	No	2
IL9R-002 ENSP00000244174 ENST00000244174	Q01113 [Direct mapping] Interleukin-9 receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004919 [interleukin-9 receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0038113 [interleukin-9-mediated signaling pathway] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	521 aa 57.1 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.