Expression of MCEE in cancer - Summary - The Human Protein Atlas

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MCEE

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MCEE
Gene description	Methylmalonyl CoA epimerase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and liver cancer (favourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MCEE (HGNC Symbol)
Synonyms	GLOD2
Description	Methylmalonyl CoA epimerase (HGNC Symbol)
Entrez gene summary	The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	71109684 - 71130239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124370 (version 83.38)
Entrez gene	84693
UniProt	Q96PE7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PE7
Antibodypedia	MCEE antibodies

PROTEIN BROWSER

MCEE-001	MCEE-002	MCEE-003	MCEE-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCEE-001 ENSP00000244217 ENST00000244217	Q96PE7 [Direct mapping] Methylmalonyl-CoA epimerase, mitochondrial Show all	Enzymes ENZYME proteins Isomerase Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004493 [methylmalonyl-CoA epimerase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0019626 [short-chain fatty acid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046491 [L-methylmalonyl-CoA metabolic process] GO:0046872 [metal ion binding] Show all	176 aa 18.7 kDa	Yes	0
MCEE-002 ENSP00000441569 ENST00000486135	F5GZ54 [Direct mapping] Methylmalonyl-CoA epimerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.4 kDa	No	0
MCEE-003 ENSP00000437361 ENST00000494660	F5GZ54 [Direct mapping] Methylmalonyl-CoA epimerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.4 kDa	No	0
MCEE-007 ENSP00000391140 ENST00000413592	H7BZS7 [Direct mapping] Methylmalonyl-CoA epimerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.