Expression of IL17C in cancer - Summary - The Human Protein Atlas

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IL17C

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL17C
Gene description	Interleukin 17C
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Secreted positivity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA065051
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065051

GENE INFORMATION
Gene name	IL17C (HGNC Symbol)
Synonyms	CX2, IL-17C, IL-21, MGC126884, MGC138401
Description	Interleukin 17C (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.2
Chromosome location (bp)	88638591 - 88640473
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124391 (version 83.38)
Entrez gene	27189
UniProt	Q9P0M4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0M4
Antibodypedia	IL17C antibodies

PROTEIN BROWSER

IL17C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL17C-001 ENSP00000244241 ENST00000244241	Q9P0M4 [Direct mapping] Interleukin-17C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005125 [cytokine activity] GO:0005126 [cytokine receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] Show all	197 aa 21.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.