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ATP8A1

GENERAL INFORMATION

Gene name

 ATP8A1

Gene description

 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland, thyroid gland)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression at variable levels in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA049948 , HPA052935
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP8A1 (HGNC Symbol)

Synonyms

 ATPIA

Description

 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (HGNC Symbol)

Entrez gene summary

 The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p13

Chromosome location (bp)

 42408373 - 42657105

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124406 (version 83.38)

Entrez gene

 10396

UniProt

 Q9Y2Q0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2Q0

Antibodypedia

 ATP8A1 antibodies

PROTEIN BROWSER
ATP8A1-001
ATP8A1-002
ATP8A1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP8A1-001
ENSP00000371084
ENST00000381668
Q9Y2Q0 [Direct mapping]
Phospholipid-transporting ATPase IA
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007612 [learning]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019829 [cation-transporting ATPase activity]
GO:0030335 [positive regulation of cell migration]
GO:0034220 [ion transmembrane transport]
GO:0042584 [chromaffin granule membrane]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0061092 [positive regulation of phospholipid translocation]
GO:0070062 [extracellular exosome]
GO:0098655 [cation transmembrane transport]
Show all
 1164 aa
131.4 kDa 		No >9
ATP8A1-002
ENSP00000426636
ENST00000510289
Q4G1C1 [Direct mapping]
ATP8A1 protein; Phospholipid-transporting ATPase IA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
Show all
 55 aa
6.5 kDa 		No 0
ATP8A1-003
ENSP00000264449
ENST00000264449
Q9Y2Q0 [Direct mapping]
Phospholipid-transporting ATPase IA
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019829 [cation-transporting ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0042584 [chromaffin granule membrane]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098655 [cation transmembrane transport]
Show all
 1149 aa
129.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.