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HIF3A

GENERAL INFORMATION

Gene name

 HIF3A

Gene description

 Hypoxia inducible factor 3, alpha subunit

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (ASC TERT1, TIME)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA041141
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041141

GENE INFORMATION

Gene name

 HIF3A (HGNC Symbol)

Synonyms

 bHLHe17, IPAS, MOP7, PASD7

Description

 Hypoxia inducible factor 3, alpha subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 46297046 - 46343433

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124440 (version 83.38)

Entrez gene

 64344

UniProt

 Q9Y2N7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2N7

Antibodypedia

 HIF3A antibodies

PROTEIN BROWSER
HIF3A-003
HIF3A-004
HIF3A-006
HIF3A-007
HIF3A-012
HIF3A-023

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIF3A-003
ENSP00000366898
ENST00000377670
Q9Y2N7 [Direct mapping]
Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 669 aa
72.4 kDa 		No 0
HIF3A-004
ENSP00000434653
ENST00000472815
H0YDZ5 [Direct mapping]
Hypoxia inducible factor 3, alpha subunit, isoform CRA_a; Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 450 aa
48.6 kDa 		No 0
HIF3A-006
ENSP00000300862
ENST00000300862
Q9Y2N7 [Direct mapping]
Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 667 aa
72.4 kDa 		No 0
HIF3A-007
ENSP00000244303
ENST00000244303
Q9Y2N7 [Direct mapping]
Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 600 aa
64.4 kDa 		No 0
HIF3A-012
ENSP00000435200
ENST00000533145
E9PLC8 [Direct mapping]
Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 148 aa
16 kDa 		No 0
HIF3A-023
ENSP00000471560
ENST00000600383
M0R104 [Direct mapping]
Hypoxia-inducible factor 3-alpha
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 594 aa
64.1 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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