Expression of LYPD3 in cancer - Summary - The Human Protein Atlas

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LYPD3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LYPD3
Gene description	LY6/PLAUR domain containing 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, MCF7, RT4, SK-BR-3)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA041529 , HPA041797
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041529	HPA041797

GENE INFORMATION
Gene name	LYPD3 (HGNC Symbol)
Synonyms	C4.4A
Description	LY6/PLAUR domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43460787 - 43465660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124466 (version 83.38)
Entrez gene	27076
UniProt	O95274 (UniProt - Evidence at protein level)
neXtProt	NX_O95274
Antibodypedia	LYPD3 antibodies

PROTEIN BROWSER

LYPD3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYPD3-001 ENSP00000244333 ENST00000244333	O95274 [Direct mapping] Ly6/PLAUR domain-containing protein 3 B2RBR3 [Target identity:100%; Query identity:100%] LY6/PLAUR domain containing 3; cDNA PSEC0157 fis, clone PLACE1008238, highly similar to Ly6/PLAUR domain-containing protein 3; cDNA, FLJ95643, Homo sapiens GPI-anchored metastasis-associated protein homolog(C4.4A), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0007160 [cell-matrix adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043236 [laminin binding] GO:0046658 [anchored component of plasma membrane] Show all	346 aa 36 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.