Expression of CEACAM8 in cancer - Summary - The Human Protein Atlas

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CEACAM8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEACAM8
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 8
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. CAB033676
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB033676

GENE INFORMATION
Gene name	CEACAM8 (HGNC Symbol)
Synonyms	CD66b, CGM6
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42580241 - 42740384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124469 (version 83.38)
Entrez gene	1088
UniProt	P31997 (UniProt - Evidence at protein level)
neXtProt	NX_P31997
Antibodypedia	CEACAM8 antibodies

PROTEIN BROWSER

CEACAM8-001	CEACAM8-002	CEACAM8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM8-001 ENSP00000244336 ENST00000244336	P31997 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Q0Z7S6 [Target identity:100%; Query identity:100%] Carcinoembryonic antigen-related cell adhesion molecule 8; cDNA, FLJ93041, Homo sapiens carcinoembryonic antigen-related cell adhesionmolecule 8 (CEACAM8), mRNA Show all	CD markers MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007596 [blood coagulation] GO:0031225 [anchored component of membrane] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	349 aa 38.2 kDa	Yes	0
CEACAM8-002 ENSP00000472166 ENST00000599005	M0R1X3 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.3 kDa	No	0
CEACAM8-201 ENSP00000484915 ENST00000614151	A0A087X2E2 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	344 aa 37.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.