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Colorectal cancers displayed nuclear, membranous and cytoplasmic positivity of weak intensity. Remaining malignant tissues were in general negative or showed weak cytoplasmic staining.
GENE INFORMATION
Gene name
NDP (HGNC Symbol)
Synonyms
EVR2, norrin
Description
Norrie disease (pseudoglioma) (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]