Fields »
ABOUT
HELP
BLOG
TRERF1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TRERF1

Gene description

 Transcriptional regulating factor 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytosol (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA027771 , HPA051273
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA027771 PC-3 Nucleus Intensity
Nucleoli Intensity
HPA027771 RT4 Nucleoplasm
HPA027771 U-2 OS Nucleoplasm
HPA051273 A-431 Nucleoplasm
HPA051273 PC-3 Nucleoplasm
Cytosol
HPA051273 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 TRERF1 (HGNC Symbol)

Synonyms

 BCAR2, dJ139D8.5, HSA277276, RAPA, TReP-132

Description

 Transcriptional regulating factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 42224931 - 42452051

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124496 (version 83.38)

Entrez gene

 55809

UniProt

 Q96PN7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PN7

Antibodypedia

 TRERF1 antibodies

PROTEIN BROWSER
TRERF1-001
TRERF1-002
TRERF1-003
TRERF1-201
TRERF1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRERF1-001
ENSP00000362013
ENST00000372922
Q96PN7 [Direct mapping]
Transcriptional-regulating factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0042592 [homeostatic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046885 [regulation of hormone biosynthetic process]
Show all
 1200 aa
132.3 kDa 		No 0
TRERF1-002
ENSP00000339438
ENST00000340840
Q96PN7 [Direct mapping]
Transcriptional-regulating factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0042592 [homeostatic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046885 [regulation of hormone biosynthetic process]
Show all
 1129 aa
125 kDa 		No 0
TRERF1-003
ENSP00000346285
ENST00000354325
Q96PN7 [Direct mapping]
Transcriptional-regulating factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0042592 [homeostatic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046885 [regulation of hormone biosynthetic process]
Show all
 1117 aa
123.6 kDa 		No 0
TRERF1-201
ENSP00000362008
ENST00000372917
Q96PN7 [Direct mapping]
Transcriptional-regulating factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0042592 [homeostatic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046885 [regulation of hormone biosynthetic process]
Show all
 956 aa
106.3 kDa 		No 0
TRERF1-202
ENSP00000439689
ENST00000541110
Q05GC8 [Direct mapping]
Breast cancer anti-estrogen resistance 2; Transcriptional-regulating factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0046872 [metal ion binding]
Show all
 1220 aa
134.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.