Expression of BTN2A2 in cancer - Summary - The Human Protein Atlas

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BTN2A2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BTN2A2
Gene description	Butyrophilin, subfamily 2, member A2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051504
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051504

GENE INFORMATION
Gene name	BTN2A2 (HGNC Symbol)
Synonyms	BT2.2, BTF2, BTN2.2
Description	Butyrophilin, subfamily 2, member A2 (HGNC Symbol)
Entrez gene summary	Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26383096 - 26394874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124508 (version 83.38)
Entrez gene	10385
UniProt	Q8WVV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVV5
Antibodypedia	BTN2A2 antibodies

PROTEIN BROWSER

BTN2A2-001	BTN2A2-002	BTN2A2-004	BTN2A2-005	BTN2A2-006	BTN2A2-007	BTN2A2-008	BTN2A2-009	BTN2A2-010	BTN2A2-011	BTN2A2-012	BTN2A2-014	BTN2A2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN2A2-001 ENSP00000349143 ENST00000356709	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 A0A024R038 [Target identity:100%; Query identity:100%] Butyrophilin, subfamily 2, member A2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	523 aa 59.1 kDa	Yes	1
BTN2A2-002 ENSP00000337117 ENST00000352867	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	407 aa 45.8 kDa	Yes	1
BTN2A2-004 ENSP00000419451 ENST00000482536	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	313 aa 35.5 kDa	Yes	1
BTN2A2-005 ENSP00000394241 ENST00000432533	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	256 aa 28.9 kDa	Yes	2
BTN2A2-006 ENSP00000417472 ENST00000469230	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	336 aa 37.7 kDa	Yes	1
BTN2A2-007 ENSP00000399308 ENST00000416795	Q8WVV5 [Direct mapping] Butyrophilin subfamily 2 member A2 A0A024R038 [Target identity:100%; Query identity:100%] Butyrophilin, subfamily 2, member A2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031324 [negative regulation of cellular metabolic process] GO:0046007 [negative regulation of activated T cell proliferation] GO:0050710 [negative regulation of cytokine secretion] GO:0070062 [extracellular exosome] Show all	523 aa 59.1 kDa	Yes	1
BTN2A2-008 ENSP00000417129 ENST00000495632	H7C4E8 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted intracellular proteins Show all		56 aa 6.7 kDa	No	0
BTN2A2-009 ENSP00000418965 ENST00000490025	C9IZY2 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	237 aa 27.3 kDa	No	1
BTN2A2-010 ENSP00000417676 ENST00000482842	C9J8R3 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	80 aa 8.8 kDa	No	1
BTN2A2-011 ENSP00000418857 ENST00000493275	C9IY66 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	239 aa 26.6 kDa	Yes	0
BTN2A2-012 ENSP00000419226 ENST00000472507	C9JWH2 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	110 aa 11.9 kDa	Yes	0
BTN2A2-014 ENSP00000417511 ENST00000494184	C9JAJ6 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	96 aa 10.7 kDa	Yes	0
BTN2A2-015 ENSP00000418176 ENST00000483410	C9J8J5 [Direct mapping] Butyrophilin subfamily 2 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	184 aa 20.1 kDa	Yes	1

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