Expression of MRS2 in cancer - Summary - The Human Protein Atlas

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MRS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRS2
Gene description	MRS2 magnesium transporter
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA017642
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), endometrial cancer (unfavourable) and thyroid cancer (unfavourable).
Ovarian cancer p<0.001 Endometrial cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017642

GENE INFORMATION
Gene name	MRS2 (HGNC Symbol)
Synonyms	MRS2L
Description	MRS2 magnesium transporter (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	24402908 - 24426194
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124532 (version 83.38)
Entrez gene	57380
UniProt	Q9HD23 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD23
Antibodypedia	MRS2 antibodies

PROTEIN BROWSER

MRS2-007	MRS2-009	MRS2-011	MRS2-201	MRS2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRS2-007 ENSP00000387441 ENST00000446191	H7BZ29 [Direct mapping] Magnesium transporter MRS2 homolog, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	182 aa 20.6 kDa	No	1
MRS2-009 ENSP00000367637 ENST00000378386	Q9HD23 [Direct mapping] Magnesium transporter MRS2 homolog, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0045016 [mitochondrial magnesium ion transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	443 aa 50.3 kDa	No	2
MRS2-011 ENSP00000367604 ENST00000378353	Q9HD23 [Direct mapping] Magnesium transporter MRS2 homolog, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0045016 [mitochondrial magnesium ion transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	408 aa 46.5 kDa	No	2
MRS2-201 ENSP00000274747 ENST00000274747	A0A0A0MQX2 [Direct mapping] Magnesium transporter MRS2 homolog, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	393 aa 44.3 kDa	No	2
MRS2-202 ENSP00000399585 ENST00000443868	Q9HD23 [Direct mapping] Magnesium transporter MRS2 homolog, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0045016 [mitochondrial magnesium ion transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	446 aa 50.6 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.