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SERPINB6

GENERAL INFORMATION

Gene name

 SERPINB6

Gene description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 6

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA009668 , HPA012736
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and ovarian cancer (favourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213141516 Renal cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 9101112131415 Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.020406080100120140160180FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009668
HPA012736

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Moderate to strong cytoplasmic staining was seen in most cancer tissues, Strongest staining in prostate, ovarian, colorectal stomach and pancreatic cancers. Squamous cell carcinomas were among the weakest.

GENE INFORMATION

Gene name

 SERPINB6 (HGNC Symbol)

Synonyms

 CAP, DFNB91, PI6, PTI

Description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 2948159 - 2972165

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124570 (version 83.38)

Entrez gene

 5269

UniProt

 P35237 (UniProt - Evidence at protein level)

neXtProt

 NX_P35237

Antibodypedia

 SERPINB6 antibodies

PROTEIN BROWSER
SERPINB6-001
SERPINB6-002
SERPINB6-003
SERPINB6-004
SERPINB6-005
SERPINB6-006
SERPINB6-201
SERPINB6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINB6-001
ENSP00000369896
ENST00000380524
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-002
ENSP00000369891
ENST00000380520
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-003
ENSP00000338358
ENST00000335686
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-004
ENSP00000369901
ENST00000380529
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-005
ENSP00000369912
ENST00000380539
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-006
ENSP00000369919
ENST00000380546
P35237 [Direct mapping]
Serpin B6
A0A024QZX3 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007605 [sensory perception of sound]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071470 [cellular response to osmotic stress]
Show all
 376 aa
42.6 kDa 		No 0
SERPINB6-201
ENSP00000484343
ENST00000612421
A0A087X1N8 [Direct mapping]
Serpin B6; Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_e
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
Show all
 395 aa
44.8 kDa 		No 0
SERPINB6-202
ENSP00000481398
ENST00000616722
A0A024QZX5 [Direct mapping]
Serpin B6; Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_d
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
Show all
 380 aa
43 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.