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XPO5

GENERAL INFORMATION

Gene name

 XPO5

Gene description

 Exportin 5

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression which in cases was combined with nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA018402 , HPA023959 , HPA029909 , HPA029910 , CAB012357
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 XPO5 (HGNC Symbol)

Synonyms

 KIAA1291

Description

 Exportin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 43522330 - 43576075

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124571 (version 83.38)

Entrez gene

 57510

UniProt

 Q9HAV4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAV4

Antibodypedia

 XPO5 antibodies

PROTEIN BROWSER
XPO5-001
XPO5-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XPO5-001
ENSP00000265351
ENST00000265351
Q9HAV4 [Direct mapping]
Exportin-5
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0031047 [gene silencing by RNA]
GO:0035281 [pre-miRNA export from nucleus]
GO:0042565 [RNA nuclear export complex]
GO:0044822 [poly(A) RNA binding]
GO:0070883 [pre-miRNA binding]
GO:1900370 [positive regulation of RNA interference]
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 1204 aa
136.3 kDa 		No 0
XPO5-015
ENSP00000387384
ENST00000455285
H0Y3W3 [Direct mapping]
Exportin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 253 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.