Expression of ABCC10 in cancer - Summary - The Human Protein Atlas

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ABCC10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCC10
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA041607 , HPA045464
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041607	HPA045464

GENE INFORMATION
Gene name	ABCC10 (HGNC Symbol)
Synonyms	EST182763, MRP7, SIMRP7
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	43427366 - 43450430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124574 (version 83.38)
Entrez gene	89845
UniProt	Q5T3U5 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T3U5
Antibodypedia	ABCC10 antibodies

PROTEIN BROWSER

ABCC10-002	ABCC10-007	ABCC10-009	ABCC10-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC10-002 ENSP00000361608 ENST00000372530	Q5T3U5 [Direct mapping] Multidrug resistance-associated protein 7 A0A024RD21 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 10, isoform CRA_b Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1492 aa 161.6 kDa	Yes	>9
ABCC10-007 ENSP00000244533 ENST00000244533	Q5T3U5 [Direct mapping] Multidrug resistance-associated protein 7 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1464 aa 158.8 kDa	No	>9
ABCC10-009 ENSP00000361593 ENST00000372515	D6R9B3 [Direct mapping] Multidrug resistance-associated protein 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	277 aa 30.5 kDa	No	2
ABCC10-011 ENSP00000422699 ENST00000505344	H0Y904 [Direct mapping] Multidrug resistance-associated protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.