Expression of NQO2 in cancer - Summary - The Human Protein Atlas

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NQO2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NQO2
Gene description	NAD(P)H dehydrogenase, quinone 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, highest expression in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA021283 , HPA021332
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021283	HPA021332

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most melanomas and testicular cancers as well as several renal and liver cancers displayed moderate cytoplasmic and/or nuclear staining. Remaining cancer were in general weakly stained or negative.

GENE INFORMATION
Gene name	NQO2 (HGNC Symbol)
Synonyms	DHQV, DIA6, NMOR2, QR2
Description	NAD(P)H dehydrogenase, quinone 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	2987987 - 3028869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124588 (version 83.38)
Entrez gene	4835
UniProt	P16083 (UniProt - Evidence at protein level)
neXtProt	NX_P16083
Antibodypedia	NQO2 antibodies

PROTEIN BROWSER

NQO2-001	NQO2-002	NQO2-003	NQO2-004	NQO2-005	NQO2-006	NQO2-007	NQO2-008	NQO2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NQO2-001 ENSP00000369822 ENST00000380455	P16083 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007613 [memory] GO:0008753 [NADPH dehydrogenase (quinone) activity] GO:0009055 [electron carrier activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	231 aa 25.9 kDa	No	0
NQO2-002 ENSP00000337773 ENST00000338130	P16083 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008753 [NADPH dehydrogenase (quinone) activity] GO:0009055 [electron carrier activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	231 aa 25.9 kDa	No	0
NQO2-003 ENSP00000369806 ENST00000380441	Q5TD07 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	193 aa 21.5 kDa	No	0
NQO2-004 ENSP00000380829 ENST00000397717	Q5TD05 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0
NQO2-005 ENSP00000369821 ENST00000380454	Q5TD07 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	193 aa 21.5 kDa	No	0
NQO2-006 ENSP00000369795 ENST00000380430	P16083 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008753 [NADPH dehydrogenase (quinone) activity] GO:0009055 [electron carrier activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	231 aa 25.9 kDa	No	0
NQO2-007 ENSP00000369839 ENST00000380472	Q5TD05 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0
NQO2-008 ENSP00000406951 ENST00000426637	A2A2U4 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 6.8 kDa	No	0
NQO2-009 ENSP00000475864 ENST00000606474	U3KQG7 [Direct mapping] Ribosyldihydronicotinamide dehydrogenase [quinone] Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.8 kDa	Yes	0

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