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MOCS1

GENERAL INFORMATION

Gene name

 MOCS1

Gene description

 Molybdenum cofactor synthesis 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA045783 , HPA058177
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and pancreatic cancer (favourable).
Cervical cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045783
HPA058177

GENE INFORMATION

Gene name

 MOCS1 (HGNC Symbol)

Synonyms

 MOCOD

Description

 Molybdenum cofactor synthesis 1 (HGNC Symbol)

Entrez gene summary

 Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]

Chromosome

 6

Cytoband

 p21.2

Chromosome location (bp)

 39899578 - 39934551

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124615 (version 83.38)

Entrez gene

 4337

UniProt

 Q9NZB8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZB8

Antibodypedia

 MOCS1 antibodies

PROTEIN BROWSER
MOCS1-001
MOCS1-002
MOCS1-005
MOCS1-006
MOCS1-008
MOCS1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOCS1-001
ENSP00000362282
ENST00000373186
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
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 385 aa
43.1 kDa 		No 0
MOCS1-002
ENSP00000362291
ENST00000373195
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
Show all
 533 aa
58.5 kDa 		No 0
MOCS1-005
ENSP00000344794
ENST00000340692
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
Show all
 636 aa
70.1 kDa 		No 0
MOCS1-006
ENSP00000416478
ENST00000425303
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
Show all
 636 aa
70.2 kDa 		No 0
MOCS1-008
ENSP00000362284
ENST00000373188
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
A0A024RD17 [Target identity:100%; Query identity:100%]
Molybdenum cofactor synthesis 1, isoform CRA_c
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
Show all
 385 aa
43.1 kDa 		No 0
MOCS1-010
ENSP00000410809
ENST00000432280
Q9NZB8 [Direct mapping]
Molybdenum cofactor biosynthesis protein 1 Cyclic pyranopterin monophosphate synthase Cyclic pyranopterin monophosphate synthase accessory protein
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061597 [cyclic pyranopterin monophosphate synthase activity]
Show all
 356 aa
40.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.