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MED20

GENERAL INFORMATION

Gene name

 MED20

Gene description

 Mediator complex subunit 20

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040717
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable) and renal cancer (favourable).
Melanoma p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040717

GENE INFORMATION

Gene name

 MED20 (HGNC Symbol)

Synonyms

 DKFZp586D2223, PRO0213, TRFP

Description

 Mediator complex subunit 20 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 41905354 - 41921139

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124641 (version 83.38)

Entrez gene

 9477

UniProt

 Q9H944 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H944

Antibodypedia

 MED20 antibodies

PROTEIN BROWSER
MED20-001
MED20-003
MED20-004
MED20-005
MED20-007
MED20-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED20-001
ENSP00000265350
ENST00000265350
Q9H944 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0061630 [ubiquitin protein ligase activity]
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 212 aa
23.2 kDa 		No 0
MED20-003
ENSP00000386668
ENST00000409060
B7ZBQ3 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 145 aa
15.9 kDa 		No 0
MED20-004
ENSP00000377795
ENST00000394251
A6PVP4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 140 aa
15.3 kDa 		No 0
MED20-005
ENSP00000403061
ENST00000434077
B7ZBQ1 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.8 kDa 		Yes 0
MED20-007
ENSP00000386816
ENST00000409312
Q9H944 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016592 [mediator complex]
Show all
 123 aa
13.5 kDa 		No 0
MED20-201
ENSP00000484159
ENST00000613074
A0A087X1F4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 20
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 211 aa
23.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.