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GNMT

GENERAL INFORMATION

Gene name

 GNMT

Gene description

 Glycine N-methyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, prostate cancer)
HPA (cell line):Cell line enhanced (SCLC-21H)
HPA (normal tissue):Group enriched (liver, pancreas, prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in liver and exocrine pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA027501
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027501

GENE INFORMATION

Gene name

 GNMT

Synonyms

Description

 Glycine N-methyltransferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 42960758 - 42963880

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124713 (version 83.38)

Entrez gene

 27232

UniProt

 Q14749 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14749

Antibodypedia

 GNMT antibodies

PROTEIN BROWSER
GNMT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNMT-001
ENSP00000361894
ENST00000372808
Q14749 [Direct mapping]
Glycine N-methyltransferase
V9HW60 [Target identity:100%; Query identity:100%]
Glycine N-methyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005542 [folic acid binding]
GO:0005737 [cytoplasm]
GO:0005977 [glycogen metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006464 [cellular protein modification process]
GO:0006555 [methionine metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0016594 [glycine binding]
GO:0017174 [glycine N-methyltransferase activity]
GO:0032259 [methylation]
GO:0046500 [S-adenosylmethionine metabolic process]
GO:0051289 [protein homotetramerization]
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 295 aa
32.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.