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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SOX4
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SOX4

Gene description

SRY (sex determining region Y)-box 4

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA, MOLT-4)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA029901
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA029901

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were moderately stained. Several cases of lymphoma, renal and liver cancers showed weak positivity.

GENE INFORMATION

Gene name

SOX4

Synonyms

Description

SRY (sex determining region Y)-box 4 (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p22.3

Chromosome location (bp)

21592769 - 21598619

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124766 (version 83.38)

Entrez gene

6659

UniProt

Q06945 (UniProt - Evidence at protein level)

neXtProt

NX_Q06945

Antibodypedia

SOX4 antibodies

PROTEIN BROWSER

SOX4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX4-001
ENSP00000244745
ENST00000244745
Q06945 [Direct mapping]
Transcription factor SOX-4
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001071 [nucleic acid binding transcription factor activity]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001501 [skeletal system development]
GO:0001841 [neural tube formation]
GO:0002328 [pro-B cell differentiation]
GO:0003183 [mitral valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003289 [atrial septum primum morphogenesis]
GO:0003357 [noradrenergic neuron differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007507 [heart development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0014009 [glial cell proliferation]
GO:0021510 [spinal cord development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021782 [glial cell development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030217 [T cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031647 [regulation of protein stability]
GO:0032024 [positive regulation of insulin secretion]
GO:0035019 [somatic stem cell population maintenance]
GO:0035910 [ascending aorta morphogenesis]
GO:0042593 [glucose homeostasis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0044798 [nuclear transcription factor complex]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0046982 [protein heterodimerization activity]
GO:0048485 [sympathetic nervous system development]
GO:0050821 [protein stabilization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060174 [limb bud formation]
GO:0060412 [ventricular septum morphogenesis]
GO:0060548 [negative regulation of cell death]
GO:0060563 [neuroepithelial cell differentiation]
GO:0060993 [kidney morphogenesis]
GO:0071333 [cellular response to glucose stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2000761 [positive regulation of N-terminal peptidyl-lysine acetylation]
Show all
474 aa
47.3 kDa
No 0

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